16-P007 A novel IFT mouse mutant shows activation of hedgehog signalling in the limb and neural tube
نویسندگان
چکیده
septum formation. Migration assays performed on primary cell cultures of myofibroblasts from wild type and Rfx3 / lungs show that Rfx3 / myofibroblasts loose their capacities to respond to environmental factors as guidance cues. We are currently dissecting the signaling cascades that are impaired in Rfx3-deficient myofibroblasts. In conclusion, RFX3 regulates primary ciliary growth and governs myofibroblast differentiation program in the developing lungs. Our work therefore suggests a novel function of primary cilia during lung development in vivo.
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009